帕罗西汀治疗抑郁症早期合用小剂量奥氮平临床观察

摘要

目的 探讨帕罗西汀治疗抑郁症早期合用小剂量奥氮平的临床疗效及不良反应.方法 将66例抑郁症患者早期治疗时随机分成帕罗西汀组(单用组)和帕罗西汀合用小剂量奥氮平组(合用组)各33例,采用汉密顿抑郁量表(HAMD)及不良反应量表(TESS)评定治疗前、治疗后1、2、4周末疗效、不良反应.结果 合用组较单用组疗效好(P＜0.05),而两组间不良反应差异无统计学意义.结论 帕罗西汀治疗抑郁症早期合用小剂量奥氮平起效快,克服了单用抗抑郁药起效慢的特点,迅速改善睡眠障碍和焦虑.提高患者治疗依从性.而不增加不良反应.%Objective To observe the clinical eficacy of paroxetine combines low dose Olanzapine in treatment of depression. Methods 60 patients with depressive disorder were randomly divided into research ( n - 30, took paroxetine combines low dose Olanzapine) and control group ( n - 30, did single paroxetine) for 4 weeks. Curative effects were assessed with the HAMD. Results There were significant diferences between the two groups by total curative after 4 weeks ( P < 0. 05 ). There were no significant diferences of the adverse reaction between the two groups. Conclusion Paroxetine combines low dose Olanzapine takes effect faster in treatment depression, conquering the shortcomings that antidepressant' s single use is a long time to onset. Improving the dyssomnia and anxious quickly.