目的：对右美托嘧啶在妇科手术硬膜外麻醉中的应用效果与用药安全性进行论证。方法2012年1月至2012年11月间妇科手术患者46例随机分为观察组23例,采用右美托嘧啶进行硬膜外麻醉；另23例患者设为对照组,采用常规麻醉方法。对两组患者术中镇静效果依据Ramsay指标与脑电双频谱指标进行评级,从而分析右美托嘧啶在妇科手术患者镇静中的用药效果与安全性。结果观察组患者使用右美托嘧啶硬膜外麻醉后脑电双频谱指数明显低于对照组患者,差异有统计学意义(P<0．05),Ramsay指标明显优于对照组,差异有统计学意义(P<0．05)；观察组患者手术中心率指标低于对照组患者,差异有统计学意义(P<0．05),两组患者未发生呼吸抑制情况。结论妇科手术中采用右美托嘧啶硬膜外麻醉方法有效率与安全性得到验证,且不会发生呼吸抑制等不良反应,能够进行临床推广。%Objective To study the effect and safety of dexmedetomidive for patients with gynecological surgery under epidural anesthesia. Methods In our hospital from January 2012 to November 2012,46 patients with gynecological surgery were randomized divided into observation group and control group,23 cases using dexmedetomudin with epidural anesthesia;23 patients were set as control group,using anesthesia,intraoperative sedation effect of two groups of patients on the basis of Ramsay indicators and computer bispectral index,to analyze the right supporting pyrimidine calm drug efficacy and safety of patients with gynecologi-cal surgery. Results The observation group of patients using the right after epidural anesthesia between computer bispectral index (P<0. 05),significantly lower than the control group patients Ramsay index is better than the control group(P<0. 05),the control group patients with two groups of indicators are no significant change;Observation group of patients with surgery center rate lower than the control group patients,two groups of patients with respiratory depression did not happen. Conclusion The gynecologic sur-gery using right beauty pyrimidine epidural anesthesia method is efficient and security validation,and won't happen adverse reactions such as respiratory depression,ability of clinical promotion.
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