血清间接胆红素、胱抑素C与脑梗死关系的探讨

摘要

Objective:To investigate the indirect bilirubin,Cystatin C with cerebral infarction,the relationship between the patho-genesis and prognosis.Methods:Fifty patients with acute cerebral infarction were collected as the case group and 50 cases of non-cer-ebral infarction as the control group,they are all over the age of 50.Indirect bilirubin (IBIL),Cystatin C (Cys C)were tested in these two groups respectively.The United States National Institutes of Health Stroke Scale (NIHSS)score were applied on the day of admission.The scores were compared between the two groups.Results:1 .The cerebral infarction group and control group in gen-der,age,smoking,diabetes and high blood pressure and so on,there was no significant difference (P>0.05).2.IBIL,Cystatin C level of cerebral infarction group is higher than the control group significantly (p < 0.05).3.Analyzing relevant factors of the cere-bral infarction group with the NIHSS scores on admission by linear correlation analysis,the results of IBIL,Cystatin C and NIHSS score was positively correlated.Conclusion:1 .In the acute phase of cerebral infarction,the levels of IBIL and Cystatin C were in-creased.2.IBIL,Cystatin C levels in the acute phase of cerebral infarction associated with its prognosis,the higher the levels of these factors the worse the prognosis.%目的：：探讨血清间接胆红素、胱抑素C与脑梗死起病及预后之间的关系。方法：选取50岁以上的脑梗死急性期患者50例为病例组,同期本科室住院的50岁以上的非脑梗死患者50例为对照组。于入院时对间接胆红素(Indirect bilirubin,IBIL)、胱抑素C(Cystatin C,Cys C)进行检测,于入院时进行美国国立卫生研究院卒中量表(The NIH Stroke Scale,NIHSS)评分,观察病例组与对照组之间上述指标的异同,并进行相关性分析。结果：1.脑梗死组与对照组在性别、年龄、吸烟、糖尿病和高血压病史等基础资料方面比较,差异无显著性(P>0.05)。2.脑梗死组 IBIL、胱抑素C水平高于对照组,差异均具有显著性(P<0.05)。3.将入院时脑梗死患者血清IBIL、胱抑素C水平与入院时NIHSS 评分进行直线相关性分析,结果提示血清IBIL、胱抑素C水平与NIHSS评分均呈正相关。结论：脑梗死急性期血清间接胆红素、胱抑素C水平增高；脑梗死急性期血清间接胆红素、胱抑素 C 水平与脑梗死预后相关,其水平越高预后越差。