猪口服免疫F18ac＋非产肠毒素大肠杆菌疫苗候选株后小肠免疫细胞的组织形态学特征

摘要

Colidiarrhea and colienterotoxemia caused by F4+ and/or F18+ enterotoxigenic F. coli (ETEC) strains are the most prevalent infections of suckling and weaned pigs. Here we tested the immunogenicity and protective effectiveness of attenuated F18ac+ non-ETEC vaccine candidate strain against challenge infection with F4a+ ETEC strain by quantitative phenotypic analysis of small intestinal leukocyte subsets in weaned pigs. We also evaluated levamisole as an immune response modifier (IRM) and its adjuvanticity when given in the combination with the experimental vaccine.%由F4＋和（或）F18＋产肠毒素大肠杆菌（ETEC）引起的腹泻和肠毒血症是乳猪及断奶仔猪的多发病。本文通过对断奶仔猪小肠淋巴样细胞亚群表型进行定量分析，检测和评估了F18ac＋非ETEC弱毒疫苗候选株对F4ac＋ETEC感染的免疫原性及保护效力：同时还评估了左旋咪唑作为一种免疫应答调节剂（IRM）的调节效能及其与试验疫苗联用的佐剂活性。