S6K1和4EBP-1蛋白在膀胱尿路上皮癌中的表达及意义

摘要

Objective To detect the expression of S6K1 and 4EBP-1 and to discuss their clinical and pathological significance in urothelial carcinoma of the bladder. Methods The expression of S6K1 and 4EBP-1 were detected in 80 urothclial carcinoma of the bladder tissues and 20 normal bladder mucosa tissues by Western blot. Results The expression rate of S6K1 in urothclial carcinoma of the bladder tissues (64%) was significantly higher than that in normal bladder mucosa tissues (10%). The expression rate of 4EBP-1 in normal bladder mucosa tissues (15%) was significantly lower than that in urothclial carcinoma of the bladder tissues (71%). The expression rates of S6K1 and 4EBP-1 protein in low-grade bladder cancer were significantly higher than those in the high-grade bladder cancer (P<0. 05). The expression rates of S6K1 and 4EBP-1 protein in recurrent tumors were higher than those in the primary tumor (P<0. 05). There was no significant difference of the expression rate of S6K1 and 4EBP-1 protein in patients with different gender, different tumor stage and with or without smoking (P>0. 05). Conclusion S6K1 and 4EBP-1 arc closely related to the pathological grade and recurrence of urothclial carcinoma of the bladder, which may become new targets for cancer therapy.%目的 探讨S6K1和4EBP-1蛋白在膀胱尿路上皮癌中的表达及意义.方法 使用免疫印迹法(Western-blot)检测S6K1和4EBP-1蛋白在80例膀胱尿路上皮癌及20例正常膀胱黏膜中的表达.结果 膀胱尿路上皮癌中S6K1蛋白表达率(64%)高于正常膀胱黏膜(10%),4EBP-1蛋白表达率(71%)高于正常膀胱黏膜(15%).S6K1和4EBP-1蛋白在低分级膀胱癌中的表达率显著高于高分级膀胱癌中的表达率.复发肿瘤的S6K1和4EBP-1蛋白表达率高于初发肿瘤.而S6K1和4EBP-1蛋白表达率在不同性别患者、不同肿瘤分期和是否吸烟患者中差异无统计学意义.结论 膀胱尿路上皮癌中S6K1和4EBP-1蛋白与膀胱癌的分级和复发相关,可能成为肿瘤诊断治疗的新靶点.