血清C反应蛋白与胆红素相关关系的Meta分析研究

摘要

目的：采用 Meta 分析的方法，评价基于相关系数的 C 反应蛋白与胆红素的相关性。方法计算机检索 PubMed 、Springerlink 、EMbase 、Cochrane 数据库，检索时限均为1990年1月至2013年7月，查找关于C 反应蛋白与胆红素相关性的文献。按照纳入排除标准筛选文献、提取资料并评价纳入研究的质量后，采用RevMan 5．2软件进行 Meta 分析。结果共检出相关文献363篇，最终仅纳入质量较高的6篇文献。 Meta 分析结果显示，C 反应蛋白与胆红素有一定负相关。结论 C 反应蛋白与胆红素存在相关关系，可以作为有限反映慢性血管炎症的指标。%Objective Meta analysis method was applied to evaluate the correlation between C-reactive pro-tein and bilirubin based on correlation coefficient .Methods Literatures related to correlation between C-reactive protein and bilirubin from January 1990 to July 2013 were retrieved from PubMed ,Springerlink ,EMbase and Co-chrane database .After screening literatures ,extracting data and assessing the quality of studies according to inclu-sion and exclusion criteria ,RevMan 5 .2 software was adopted to do Meta-analysis.Results Three hundred and sixty-three relevant literatures were retrieved ,and finally only six literatures of high quality were included .Meta-analysis showed that there is negative correlation between C-reactive protein and bilirubin .Conclusion Correlation between C-reactive protein and bilirubin can be taken as limited indicators to reflect chronic vascular inflammation.