Objective To investigate the clinical value of standard ultrasound in fetal malformations in the pregnancy period of 11 to 13 + 6 weeks .Methods Five hundred and eighty-six cases of pregnant women were in-cluded in this study form April 2013 to April 2014 in our hospital .All pregnant women are using conventional ul-trasound and 8 standard ultrasound views ,such as longitudinal section ,sagittal section ,head ,chest and abdomen section ,upper and lower limbs section ,bladder section .The efficacy of standard ultrasound in fetal malformations in the pregnancy period of 11 to 13 + 6 weeks was analyzed .Results Eight of the included 586 cases were found to be abnormal .The main malformation were skull defect ,endocardial cushion defect ,closed chest ,gastroschisis , no brain ,omphalocele ,brain malformation ,endocardial cushion defect and edema .The diagnostic results was in accordance with the pre-ultrasound examination with no statistical difference ( P > 0.05) .Seven of the 8 malfor-mation fetus were received induction of labor and another with edema .The diagnostic coincidence rate was 98 .3%with no statistical difference to the postnatal diagnosis( P > 0.05) .Ten cases were missed by the standard ultra-sound (Five cases of heart malformation ,2 cases of omphalocele ,2 cases of diaphragmatic hernia ,and 1 case of ear deformity) .Conclusion During 11 ~ 13 + 6 weeks of early pregnancy ,the standard ultrasound view can be use-ful for diagnosis of fetal exencephaly ,no brain in cardiac and other severe fetal deformity .But for the heart and great vessel anomalies ,and limb deformity ,the stand ultrasound can't provide effective diagnosis .So ,the screen-ing in the early ,mid and late pregnancy should be established in order to reduce the rate of fetal malformation .%目的：探讨标准超声切面在孕11～13＋6周胎儿结构畸形胎儿筛查中的临床价值及效果。方法选取2013年4月至2014年4月我院诊治的586例孕妇资料进行分析，入选孕妇均采用常规超声检查和8个标准超声切面对其进行检查，即：纵切面、颈项矢状切面、颅脑切面、胸部切面、腹部切面、膀胱切面、上肢和下肢切面，分析标准超声切面在孕11～13＋6周胎儿结构畸形胎儿结构畸形筛查中的应用效果。结果入选的586例孕妇中共有8例筛查异常，主要包括：颅骨缺损、心内膜垫缺损、胸外心、腹裂、无脑、脐膨出、颅脑畸形、心内膜垫缺损、水肿，大体标本与产前超声诊断相符，诊断结果相比差异无统计学意义（P＞0.05）。8例缺损胎儿7例引产，1例水肿胎儿出生，后检查并未见异常；标准超声筛查切片诊断符合率为98．3％，和胎儿出生后诊断差异无统计学意义（P＞0.05）；标准超声筛查切面10例出现漏诊（5例心脏畸形，2例脐膨出，2例膈疝，1例耳畸形），漏诊率为1.7％。结论孕11～13＋6周孕妇早期采用标准超声切面检查能够及时发现胎儿露脑、无脑胸外心等严重胎儿畸形，但是对于心脏大血管畸形以及肢体畸形无法诊断，应该建立孕早、孕中以及晚期筛查，降低胎儿畸形率。
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