培哚普利吲达帕胺在高血压患者治疗中的临床疗效分析与安全性评价

摘要

Objective To study the clinical efficacy and safety of different regimens for hypertension .Meth-ods Ninety cases patients with hypertension ,who were from outpatient and the inpatient department ,were cho-sen as the research sujects from Jan .2016 to Dec .2016 .With the method of random grouping ,all patients were randomly divided into treatment group and control group according to the random number table method .Patients of control group were treated by amlodipine besylate tablet jointed indapamide sustained-release tablets .Patients of treatment group were treated by perindopril split indapamide tablets ,the clinical curative effect and adverse reac-tion of two groups were recorded and compared .All data were analyzed by SPSS 22 .0 statistic software ,x2 test and t test were used for comparison between the two groups .Results There was significant difference between treatment group and control group for systolic blood pressure and diastolic blood pressure after treatment ( P<0.05);There was significant difference between treatment group and control group for the valley peak of systolic blood pressure (P<0.05);There was significant difference between treatment group and control group of blood pressure smoothness index (P<0.05);There was not significant difference between treatment group and control group for the valley peak of diastolic blood pressure and heart rate (P>0.05);The clinical efficacy was better than that in the control group ,and there was no statistical difference in adverse reactions .Conclusion With low adverse reaction rate ,perindopril indapamide tablets for hypertension treatment has significant efficiency ,which is worthy to be spread in clinical application .%目的 研究培哚普利吲达帕胺片治疗高血压患者的临床疗效及安全性评价.方法 选取2016年1月至12月,我科门诊及住院部收治高血压患者90例作为研究对象,按照随机数字表法将90例患者分为试验组和对照组,对照组采用苯磺酸氨氯地平片联合吲达帕胺缓释片进行治疗,试验组患者采用培哚普利吲达帕胺片,记录并比较2组患者的临床疗效及不良反应.应用SPSS 22.0统计学软件,比较用x2检验及用t检验,以P<0.05为差异具有统计学意义.结果 试验组患者治疗后收缩压、舒张压均较对照组患者低,组间比较差异具有统计学意义(P<0.05);试验组患者的收缩压降压谷峰比与对照组比较,差异有统计学意义(P<0.05);试验组患者与对照组患者血压平滑指数比较,差异有统计学意义(P<0.05);2组患者的舒张压降压谷峰比较及治疗前后心率比较,差异无统计学意义(P>0.05);试验组患者临床疗效优于对照组,不良反应方面比较差异无统计学意义.结论 培哚普利吲达帕胺片治疗高血压效果显著,不良反应率低,可临床推广.