2型糖尿病患者血管性认知功能障碍发生机制的研究进展

摘要

血管性认知功能障碍（vascular cognitive impairment, VCI）是由脑血管病及血管性危险因素引起的一组以认知功能受损为特点的临床综合征。2型糖尿病是认知功能障碍的危险因素，而认知功能受损又会影响到2型糖尿病患者对血糖水平的自我管理能力，导致其脑血管并发症及低血糖事件发生率增加，从而进一步加重认知功能障碍。本文概要介绍2型糖尿病相关VCI的发生机制，以期为2型糖尿病患者VCI的预防与治疗提供新思路。%Vascular cognitive impairment (VCI) is deifned as a group of clinical syndromes characterized by cognitive impairment caused by various cerebral vascular diseases and vascular risk factors. Type 2 diabetes is an independent risk factor for vascular cognitive impairment, and cognitive dysfunction can impair the ability for patients to self-manage blood glucose levels, which can result in the increase of the risk of cerebrovascular diseases and hypoglycemia events and further accelerate the cognitive impairment. In this review, we summarize the pathogenesis of vascular cognitive impairment associated with type 2 diabetes so as to provide new ideas for the prevention and treatment of VCI.