Objective To evaluate the clinical efficacy of acupuncture plus acupoint application in treating irritable bowel syndrome with diarrhea (IBS-D).Method Sixty patients were randomized into two groups, 30 cases in each group. The acupuncture group was intervened by acupuncture at Neiguan (PC6), Zhongwan (CV12), and Zusanli (ST36), etc, plus application withBai Jie Zi(Semen Brassicae) powder at Qihai (CV6), Guanyuan (CV4), and Tianshu (ST25), etc; the medication group was prescribed with oral administration of Trimebutine maleate capsules (0.2 g each dose, 3 times a day). Four-week treatment was taken as a course. The symptoms score and quality of life (QOL) scale were evaluated prior to and after the treatment.Result The clinical symptoms were significantly improved in the acupuncture group, and the total effective rate was89.3%, significantly higher than 63.0% in the medication group (P<0.05). After 4-week treatment, the clinical symptoms scores of the two groups were analyzed by rank-sum test (Z=-19.627,P=0.000<0.05), revealing a significant difference between the two groups and indicating that the improvements of clinical symptoms in the acupuncture group were more significant than those in the medication group. After 4-week treatment, the general QOL scores of the two groups were examined by rank-sum test (Z=-10.039, P=0.000<0.05), revealing a significant difference between the two groups and indicating that the improvement of QOL in the acupuncture group was superior to that in the medication group.Conclusion Acupuncture plus acupoint application can obviously mitigateabdominal pain and discomfort.%目的 评价针刺配合穴位贴敷治疗腹泻型肠易激综合征的临床疗效.方法 将60例患者随机分为两组,每组30例.针刺组予针刺内关、中脘、足三里等穴,配合白芥子散贴敷气海、关元、天枢等穴;药物组口服马来酸曲美布汀胶囊(每次0.2 g,每日3次).4星期为1个疗程.评估治疗前、后患者临床症状积分及生活质量量表评分变化.结果 针刺组可显著改善患者临床症状,总有效率为89.3%,优于药物组的63.0%(P<0.05).治疗4星期后,两组临床症状积分进行秩和检验(Z=-19.627,P=0.000<0.05),两组差异有统计学意义,提示针刺组临床症状改善程度明显优于药物组.治疗4星期后,两组患者QOL量表总评分进行秩和检验(Z=-10.039,P=0.000<0.05),两组差异有统计学意义,提示针刺组生活质量改善程度明显优于药物组.结论 针刺配合穴位贴敷治疗可明显缓解腹泻型肠易激综合征患者腹痛与腹部不适程度.
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