自体造血干细胞移植治疗血管内大B细胞淋巴瘤1例

摘要

Objective To study the diagnosis and treatment of a patient with intravascular large B-cell lymphoma ( IVLBCL).Method To report a 49-year-old female case diagnosed IVLBCL and treated with autologous hematopoietic stem cell transplantation, and to review her relative clinical data. Results The patient was diagnosed IVLBCL through lung and kidney biopsy, and got complete remission after receiving 6 courses of rituximab-CHOP chemotherapy and then treated 1 course of rituximab-CHOPE followed by autologous peripheral hematopoietic stem cell mobilization and collection. She underwent salvage therapy of rituximab-CBV followed by autologous stem-cell transplantation (ASCT) in May 2008. After that, rituximab was given to her as consolidation and maintenance therapy. She remained free of disease over the follow-up period of 25 months after transplantation. Conclusion In this case of IVLBCL, chemical therapy of rituximab-CHOP regimen and high-dose therapy (HDT) followed by ASCT combined with rituximab maintenance had carried out effective results.%目的 探讨血管内大B细胞淋巴瘤(IVLBCL)的诊治.方法 报告经自体造血干细胞移植治疗的1例女性IVLBCL患者的诊治经过,并复习相关文献.结果 患者经肺活检及肾脏活检病理诊断为IVLBCL.经过R-CHOP方案6个疗程治疗后取得完全缓解,再经R-CHOPE方案1个疗程并动员采集自体外周血干细胞,行R-CBV方案为预处理方案的自体外周血干细胞移植,之后用利妥昔单抗巩固及维持治疗.术后随访25个月,患者持续完全缓解状态.结论 本例IVLBCL患者采用R-CHOP联合自体外周血干细胞移植治疗及利妥昔单抗巩固维持取得满意疗效.