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Compositions comprising cd19xcd3 bispecific antibodies for the treatment of tumorous mass of lymph node tissue and/or extranodal lymphoma caused by diffuse large b cell lymphoma (dlbcl)
Compositions comprising cd19xcd3 bispecific antibodies for the treatment of tumorous mass of lymph node tissue and/or extranodal lymphoma caused by diffuse large b cell lymphoma (dlbcl)
The present invention provides means and methods for treating diffuse large B cell lymphoma (DLBCL). Specifically, a bispecific CD19 x CD3 antibody which engages T cells via its CD3 binding portion and concomitantly binds to CD19 on the surface of, in particular, lymphoma cells via its CD19 binding portion (i.e. a bispecific T cell engager, "BiTE") is administered for use in the treatment of tumorous mass of lymophoreticular tissue and/or extranodal lymphoma caused by DLBCL in a patient.
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机译:本发明提供了用于治疗弥漫性大B细胞淋巴瘤(DLBCL)的手段和方法。具体而言,双特异性CD19 x CD3抗体是通过其CD3结合部分与T细胞结合,并通过其CD19结合部分与特别是淋巴瘤细胞表面的CD19结合(即双特异性T细胞结合剂“ BiTE”)。用于治疗患者的DLBCL引起的淋巴球组织和/或结外淋巴瘤的肿瘤块。
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