大肠癌组织中SOX4蛋白的表达变化及意义

摘要

Objective To observe the changes of SOX4 protein expression in colorectal carcinoma(CRC) and investigate the significance. Methods The expression of SOX4 protein in normal colorectal mucosae and primary CRCs was detected using immunohistochemistry. Results The expression levels of SOX4 protein in CRC tissues were significantly higher than those in normal colorectal mucosa tissues (P<0.01). The expression of SOX4 protein in CRCs with lymph node metastasis was significantly higher than those without lymph node metastasis (P <0. 01). The SOX4 protein expression, showing no correlation with the differentiation of CRC (P>0.05) , was positively correlated with the infiltrating depth of carcinomas (P<0.01). Conclusion SOX4 protein, highly expressed in CRCs, is related to the infiltrating and metastasis of CRC and might be a valuable marker for the carcinogenesis and progression of CRC.%目的 观察SOX4蛋白在大肠癌组织中的表达变化,并探讨其意义.方法 采用免疫组化SP法对大肠正常黏膜及原发大肠癌组织中的SOX4蛋白进行检测.结果 SOX4蛋白在大肠癌组织中的表达水平显著高于大肠正常黏膜组织(P＜0.01)；有淋巴结转移的大肠癌组织中SOX4蛋白表达水平明显高于无淋巴结转移者(P＜0.01)；SOX4蛋白表达水平与癌组织浸润肠壁深度有关(P＜0.01),而与癌细胞分化程度无关(P＞0.05).结论 SOX4蛋白在大肠癌组织中高表达,与大肠癌的浸润转移有关,可作为大肠癌发生发展的预测指标之一.