治疗前患者外周血 PLR 与宫颈鳞状细胞癌预后的关系

摘要

Objective To investigate the correlation between peripheral blood platelet-lymphocyte ratio ( PLR) before treatment and the prognosis in patients with cervical squamous carcinoma.Methods The clinicopathologic data of 143 ca-ses of patients with cervical squamous carcinoma were retrospectively analyzed.According to the statistical method, we se-lected the cut-off value.The patients were divided into different groups based on the cut-off value of PLR.Then we ana-lyzed the relationships of PLR with the prognosis and the reoccurrence of patients with cervical squamous carcinoma and the clinicopathologic parameters.Results We selected PLR=125 as the cut-off value.The 5-year survival rate of high PLR group (PLR≥125) was 54.5%, the 5-year survival rate of low PLR group (PLR<125) was 81.6%;the recurrence rates were respectively 50%and 22.4%;and the difference was statistically significant (all P<0.05).PLR was related with the age of patients, FIGO stage, preoperative chemotherapy, the diameter of the tumor and the number of platelet.The prognosis of patients was related with FIGO stage, the diameter of the tumor, preoperative chemotherapy or not, PLR and the number of platelet.Cox regression analysis showed that PLR, FIGO stage, the number of platelet, the diameter of the tumor and preoperative chemotherapy were the independent risk factors for the survival and prognosis of patients with cervi-cal squamous carcinoma.Conclusion The peripheral blood PLR before treatment is associated with the prognosis of pa-tients with cervical squamous carcinoma, which can be used as the indicator for evaluating cervical squamous carcinoma.%目的：探讨治疗前外周血血小板与淋巴细胞比（ PLR）和宫颈鳞状细胞癌患者预后的关系。方法回顾性分析143例宫颈鳞状细胞癌患者的临床病理资料，根据统计学方法选取PLR截断值，将患者根据截断值分组，分析PLR与宫颈鳞状细胞癌患者生存、复发情况的关系以及与临床病理参数的关系。结果选取PLR＝125作为截断值。 PLR≥125者及PLR＜125者5年生存率分别为54．5％、81．6％，复发率分别为50．0％、22．4％，两组比较，P均＜0．05。 PLR与宫颈鳞状细胞癌患者年龄、FIGO分期、术前化疗、病灶直径、血小板计数有关，患者预后与宫颈鳞状细胞癌FIGO分期、病灶直径、术前有无化疗、PLR、血小板计数有关。 Cox回归分析显示，PLR、FIGO分期、血小板计数、病灶直径、术前是否有化疗是影响是宫颈鳞癌患者术后生存和复发的独立危险因素。结论治疗前外周血PLR与宫颈鳞状细胞癌患者预后有关，其可作为宫颈鳞状细胞癌患者病情评估的指标。