温经祛瘀方对子宫内膜病变不孕患者 IV F-E T周期子宫内膜形态变化及妊娠的影响

摘要

Objective To explore the effect of Wenjingquyufang on endometrial pattern and pregnancy rate of in infertil -ity patients with endometrial pathological changes for in vitro fertilization and embryo transfer (IVF-ET).Methods A total of 60 infertility patients with endometrial pathological changes for IVF-ET were divided into Chinese traditional medicine group (n=30) and control group(n=30) randomly.The control group patients take controlled ovarian hyperstimulation after they had hysteroscopy and curettage for Pathological examination .The patients of Chinese traditional medicine group had taken Wenjingquyufang for a week during hysteroscopy and curettage finished and menstruation .The data of clinical and laborary were compared between the two groups .Results There was significantly different on A and C endometrial pattern between two groups (P<0.05).Their biochemical pregnancy rate was different (P<0.05).The stimulation days and dose of gonado-tropic hormone, average numbers of retrieved oocytes and fertilization rate , high quality embryo rate and the number of embry-os transferred were no statistical significance compared with their inter-group(all P>0.05).On the day of human chorionic gonadotropin injection , the depth of endometrium , the serum level of estradiol , progesterone , luteinizing hormone and the number of cancel transfer were no significant difference between two groups (all P>0.05).Conclusion Wenjingquyufang can improve endometrial pattern , embryo implantation rate and clinical pregnancy rate in infertility patients with endometrial pathological changes for in vitro fertilization and embryo transfer .It has no influence on controlled ovarian hyperstimulation .%目的：探讨温经祛瘀方对子宫内膜病变不孕症患者体外受精—胚胎移植（ IVF-ET）周期子宫内膜形态变化与临床妊娠的影响。方法将60例接受IVF-ET的子宫内膜病变不孕症患者随机分为观察组（30例）和对照组（30例），对照组单纯宫腔镜下诊刮送病理检查后采用常规控制性超促排卵方案，观察组在对照组治疗的基础上辨证运用温经祛瘀方进行中药干预，观察两组患者IVF-ET周期临床与实验室相关检测指标变化。结果与对照组比较，观察组可以显著提高子宫内膜病变不孕症患者HCG注射日A型子宫内膜形态＞降低C型或不均质子宫内膜的出现（P均＜0．05）；观察组生化妊娠率高于对照组（P＜0．05）。两组促性腺激素使用时间、用量、获卵数、受精率、优胚率、移植胚胎数、HCG注射日子宫内膜厚度、血清雌二醇、孕酮、黄体生成素、周期取消率比较差异均无统计学意义（ P均＞0．05）。结论 IVF-ET周期温经祛瘀方能有效改善子宫内膜病变不孕症患者的子宫内膜形态，提高胚胎种植率与临床妊娠率。