Objective ? To investigate the change of peripheral leukocyte count and classification and neutrophil /lymphocyte ratio in the patients with coronary heart disease (CAD), methods : patients with coronary artery disease were recruited in this study , including 41 cases of acute myocardial infarction patients (AMI group) and 62 cases of unstable angina patients (UAP group) and 52 cases of stable angina patients (SAP group) . 35 cases of healthy subjects were chosen as the control group , peripheral leukocyte count and the proportion of different kinds of leukocyte were measured by the auto blood counter, neutrophil /lymphocyte ratio were calculated. Results : The leukocyte count and the proportion of neutrophil and neutrophil/lymphocyte ratio were higher in CHD group than those in control group( F< 0. 01 ) The leukocyte count, the proportions of neutrophil, neutrophil/ lymphocyte ratio were higher in AMI group than those in control group and UAP group and SAP group (P< 0. 05). The proportion of monocyte were higher in AMI group than those in the control group and SAP group(P< 0. 05). The proportion of lymphocyte was lower in AMI group than those in the control group and SAP group( P< 0. 05). The leukocyte count, the proportions of neutrophil, neutrophil/ lymphocyte ratio were higher in UAP group than those in the control group(P<0. 05) conclusion -It play an important role in estimating severity of coronary artery disease that the change of peripheral leukocyte count and classification and neutrophil /lymphocyte ratio.%目的:探讨冠心病患者外周血白细胞计数及其分类的比例及中性粒细胞与淋巴细胞比值(N/L)的变化及意义.方法:入选病例为我院2009年3月至2011年2月住院155例冠心病患者(心肌梗死41例、不稳定心绞痛62例,稳定性心绞52例),以同期健康体检者35例作为对照组.用XS800i全自动五分类血细胞分析仪计数并分类检测白细胞计数及白细胞分类比例,并计算N/L比值.结果:冠心病组患者的白细胞计数、中性粒细胞比例、N/L比值均高于正常对照组,差异均有统计学意义(P＜0.01)；AMI组白细胞计数、中性粒细胞比例、N/L比值均高于正常对照组、UAP组、SAP组,差异均有统计学意义(P＜0.05),其单核细胞高于正常对照组、SAP组,差异均有统计学意义(P＜0.05),其淋巴细胞比例低于正常对照组、SAP组,差异均有统计学意义(P＜0.05); UAP组白细胞计数、中性粒细胞比例、N/L值均高于正常对照组,差异均有统计学意义(P＜0.05).结论:外周血白细胞计数及其分类的比例、N/L比值的变化对于评估冠心病的病情的严重程度有重要意义.
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