他克莫司软膏治疗激素依赖性皮炎疗效观察

摘要

Objective:To investigate the clinical efficacy and safety of Topical Tacrolimus ointment 0. 1% in the treatment of patients with corticosteroid dependent dermatitis. Methods:68 patients were divided into 2 groups randomly. Group 1 was treated with. Tacrolimus ointment 0. 1 % 2 times a day for 4 weeks. Group 2 was treated with zinc oxide ointment 2 times a day for 4 weeks. At the same time the patients of group 2 oral cetirizine lOmg once a day. Results: All patients completed the whole course of treatment. After treatment the effective rate of group 1 and group 2 were 97. 06% and 61. 76% respectively. There was significant statistic difference in clinical efficacy(P<0. 05). Conclusion; Topical Tacrolimus 0. 1% is a better choice for patients with corticosteroid dependent dermatitis because of better clinical efficacy and safety.%目的:观察他克莫司软膏治疗激素依赖性皮炎的临床疗效和安全性.方法:将68例患者随机分为两组,治疗组外用0.1％他克莫司软膏,每日两次；对照组外用氧化锌软膏,每日两次,并口服盐酸西替利嗪分散片10mg/d,4周为1疗程.结果:治疗组有效率97.06％,对照组有效率61.76％,两组治愈率和有效率比较,差异有统计学意义(P＜0.05).结论:他克莫司软膏治疗激素依赖性皮炎疗效好、副作用少.