慢性心衰患者CA125与N-末端脑钠素原及心功能相关性研究

摘要

目的：探讨慢性心衰患者血清肿瘤抗原糖类抗原125（C A 125）与N‐末端脑钠素原（WT‐‐ProBNP）及心功能相关性。方法：选择慢性心衰患者108例，根据NYHA 心功能分级标准进行分级，分别检测CA19‐9、CA125、NT‐ProBNP、E／E’及左心射血分数（LVEF）并检测LVEF及E／E’。结果：III级患者CA125、NT‐ProBNP较II级患者均出现显著性升高（P＜0．05），IV级患者较II、III级患者均出现显著性升高（P＜0．05）。III级患者LVEF、E／E’较II级患者均出现显著性差异（P＜0．05），IV级患者LVEF较II级患者均出现显著性升高（P＜0．05），E／E＇较II、III级患者均出现显著性升高（P＜0．05）。CA125与NT‐ProBNP、E／E＇显著正相关（P＜0．05），与LVEF显著负相关（P＜0．05）。结论：CA125与心功能相关指标密切相关，对其水平检测有助于明确慢性心衰的进展。%Objective:To investigate correlation analysis of CA125 and N‐terminal pro‐brain natriuretic peptide and cardiac function in patients with chronic heart failure .Methods :108 patients with chronic heart failure were classified according to NYHA class grading standards ,CA19‐9 ,CA125 ,NT‐ProBNP ,E /E'and LVEF and detect LVEF and E /E'were detected .Results :In stage III patients CA125 ,NT‐ProBNP than stage II patients were significantly higher (P <0 .05) ,stage IV patients than stage II ,stage III patients were significantly higher (P <0 . 05) .LVEF ,E /E'in III patients compared with grade II patients were significantly different (P <0 .05) ,LVEF in grade IV was higher than that in grade II patients (P <0 .05) ,E /E'than grade II and grade III were significantly higher(P <0 .05) .CA125 and NT‐ProBNP ,E /E'showed significant positive correlation (P <0 .05) ,and LVEF was significantly negatively correlated (P <0 .05) .Conclusion:CA125 is closely related to heart function related in‐dicators ,which help to predict progress of chronic heart failure .