妊娠合并亚临床甲状腺功能减退症对妊娠结局和胎儿的影响

摘要

Objective :To investigate the obstetric and neonatal outcomes in patients with subclinical hypo-thyroidism during gestation .Methods :A research of 156 patients who suffer subclinical hypothyroidism during gesta-tion was conducted .The level of thyroid hormone were detected .Thyroxine dose requirement were close recorded . Obstetric and neonatal outcomes were variables observed .Results :The thyroxine dose increased significantly during pregnancy ,associated with appropriate suppression of TSH levels in the second and third trimesters .The cesarean section rates and abortion rate were higher in the study cohort compared with those in the control group (P<0 .05) . Conclusion :The level of thyroid hormone must be monitored throughout gestation .Thyroxine dose requirement are increases during pregnancy and thus adjusted the dose appropriately is necessary throughout gestation .These also de-crease the bad obstetric and neonatal outcomes .%目的：探讨妊娠合并亚临床甲状腺功能减退症对妊娠结局及胎儿的影响。方法：研究156例妊娠合并亚临床甲状腺功能减退症病人在孕期甲状腺功能的变化，记录左旋甲状腺激素剂量变化情况，分析妊娠结局和胎儿情况。结果：妊娠合并亚临床甲状腺功能减退症妇女妊娠中期和晚期TSH的浓度水平与孕初相比差异有统计学意义（P＜0．01）。妊娠中期和晚期对甲状腺素的需求剂量增加，与孕初相比差异有统计学意义（P＜0．01）。妊娠合并亚临床甲减者的剖宫产率和流产率明显高于正常对照组，两组比较差异有统计学意义（P＜0．05）。结论：对妊娠合并亚临床甲状腺功能减退症的孕妇应定期监测甲功变化，妊娠期间甲状腺激素的需求量增加，应及时调整用药剂量，以减少不良妊娠结局的发生。