哮喘儿童布地奈德持续吸入对血清白细胞介素23影响的临床研究

摘要

目的：探讨持续吸入布地奈德对儿童哮喘的疗效及对血清中白细胞介素-23（IL-23）影响。方法：选择200例哮喘患儿作为哮喘组，并选择200例体检健康儿童作为对照组，采用ELISA法对比哮喘患儿和正常儿童血清IL-23的水平以及哮喘患儿治疗前后血清IL-23的水平。结果：对照组血清IL-23水平 M 值为2．4 m g／L ，Q25～ Q75为1．2～5．6g／L ；哮喘组相应指标为15．3mg／L、6．1～28．7g／L ，两组比较差异有统计学意义（P〈0．05）；哮喘组患儿治疗前血清IL-23水平M 值为15．3mg／L ，Q25～Q75为6．1～28．7g／L ；治疗后，相应指标为2．5mg／L、1．5～5．7g／L ，治疗前后比较有统计学差异（P〈0．05）。结论：IL-23参与了哮喘发生发展，持续吸入布地奈德可以提高哮喘儿童的疗效，且能调节血清中IL-23水平，值得进一步研究。%Objective :To investigate the clinical efficacy of continuous inhalation of budesonide in treat-ment of childhood asthma and its effect on serum IL-23 .Methods:200 cases of children with asthma and 200 cases of healthy children from March 2014 to March 2015 in our hospital were selected as asthma group and control group , and then contrast the levels of serum IL-23 of two groups and before and after treatment in asthmatic group by the ELISA method .Results :The level of serum IL-23 were statistically significant between two groups which M value was 2 .4 mg/L ,Q25 ~ Q75 was (1 .2 ~ 5 .6 g/L) in control group ;Corresponding index is 15 .3 mg/L ,(6 .1 ~28 .7 g/L) in asthma group (P = 0 .0032) .The level of serum IL-23 were statistically significant between before and after treatment in asthmatic group which M value was 15 .3 mg/L ,Q25 ~ Q75 is (6 .1 ~ 28 .7) g/L in before treatment ;Corresponding index is 2 .5 mg/L and (1 .5 ~ 5 .7) g/L in after treatment (P=0 .0041) ,there were sta-tistically significant between before and after treatment .Conclusion:IL-23 participated in the development of asth-ma ,continuous inhalation of budesonide can improve the curative effect of childhood asthma ,and can adjust the level of serum IL-23 ,it deserves further research .