辛伐他汀联合阿司匹林治疗脑血栓190例疗效观察

摘要

目的:探讨辛伐他汀联合阿司匹林治疗脑血栓患者的临床效果.方法:将380例脑血栓患者按随机分为两组,对照组在常规治疗基础上给予阿司匹林肠溶片口服,观察组在对照组基础上再给予辛伐他汀口服,比较两组患者颈动脉内膜中层厚度(IMT)和颈动脉斑块面积变化TG、TC、HDL-C、LDL-C、Barthel指数、NIHSS量表评分等指标变化.结果:治疗后两组患者IMT、斑块面积、TG、TC及LDL-C均显著降低(P<0.05),且观察组治疗后症状改善均明显好于对照组(P<0.05),两组HDL-C治疗前后未发生明显改变(P>0.05);治疗后两组患者NIHSS显著降低及Barthel指数评分显著升高(P<0.05),且观察组改变更明显,均明显好于对照组(P<0.05).结论:采用辛伐他汀联合阿司匹林治疗脑血栓疗效显著,减轻神经功能缺损,缩小颈动脉斑块面积及厚度.%Objective:To explore the clinical effect of the combination of simvastatin and Aspirin in the treatment of patients with cerebral thrombosis.Methods:380 cases with cerebral thrombosis,according to random number table method.The control group were given Aspirin enteric-coated tablets,while the observation group of patients were given simvastatin based on the control group.Compared the change of IMT and carotid plaque area,TG,TC,HDL-C,LDL-C,Barthel index,NIHSS scale score.Results:After treatment,IMT,plaque area,TG,TC、LDL-C、NIHSS of two groups of patients were significantly lower(P<0.05),and the improvement of symptoms after treatment in observation group were better than that in the control group(P<0.05).HDL-C of two groups did not significantly change after the treatment(P>0.05).Conclusion:Simvastatin combined with Aspirin to treat patients with cerebral thrombus can reduce the nerve function defect,narrow carotid artery plaque area.Therefore,it is worth popularizing in clinical application.