回生甘露丸对肺结核继发性纤维化患者血清炎性因子及纤维化指标的影响

摘要

Objective:To explore the curative effect of Huisheng Ganluwan on pulmonary fibrosis of pulmonary tuber-culosis patient .Methods:94 patients with pulmonary fibrosis and tuberculosis were divided into the control group (47 cases) and observation group (47 cases) .The control group was given regular treatment .The observation group was given Huisheng Ganluwan on the basis of control group .The treatment time was 12 months .After the treatment ,the effect and sputum nega-tive conversion rate were observed .Before and after the treatment ,the levels of lung function index (FEV1 ,DLCO and FVC) , inflammatory factor (TNF-α,hs-CRP and IL-8) ,fibrosis markers (HA ,PC-Ⅲ ,Ⅳ-C and LN) in the 2 groups were detected . Results:The total effective rate and sputum negative conversion rate were 87 .2% and 68 .0% in the observation group ,sig-nificantly higher than control group (P<0 .05) .After the treatment ,the levels of FEV1 ,DLCO and FVC were significantly higher ,while TNF-α,hs-CRP ,IL-8 ,HA ,PC-Ⅲ ,Ⅳ-C and LN levels were significantly lower in the observation group than control group (P<0 .05) .Conclusion:Huisheng Ganluwan on pulmonary fibrosis of pulmonary tuberculosis is affirmative .%目的:探讨回生甘露丸对肺结核继发性纤维化患者血清炎性因子及纤维化指标的影响.方法:将94例肺结核继发性纤维化患者随机平均分为观察组(47例)和对照组(47例).所有患者均进行常规抗结核治疗.观察组另给予口服回生甘露丸.治疗时间为12个月.治疗后,观察两组临床疗效及痰菌转阴率.治疗前后,检测两组FEV1、DLCO及FVC等肺功能指标水平.治疗前后,检测两组患者血清TNF-α、hs-CRP、IL-8等炎性因子,HA、PC-Ⅲ 、Ⅳ-C及LN等纤维化指标含量.结果:治疗后,观察组总有效率、痰菌转阴率分别为87.2%和68.0%,明显高于对照组(P<0.05).治疗后,观察组FEV1、DLCO及FVC水平均明显高于对照组(P<0.05),TNF-α、hs-CRP、IL-8、HA、PC-Ⅲ 、Ⅳ-C及LN则明显低于对照组(P<0.05).结论:回生甘露丸对肺结核继发性纤维化具有较好的疗效.