扶正肝复丸联合恩替卡韦治疗肝脾湿热证慢性乙型肝炎临床研究

摘要

Objective :to investigate the clinical effect of Fuzheng Ganfu pill combined with entecavir in the treatment of chronic hepatitis B with dampness and heat of liver and spleen .Methods :79 patients with chronic hepa-titis B with dampness and heat syndrome of liver and spleen were randomly divided into control group and observa-tion group .The control group was treated with entecavir ,and the observation group took Fuzheng Ganfu pill on the basis of the control group .Comparative analysis of the two groups of patients before and after treatment of clinical ef-ficacy .Results :after 16 weeks of treatment ,the total effective rate was 94 .6% in the observation group ,71 .4% in the control group ,(3 .05 ± 6 .16)score in the observation group ,(6 .26 ± 7 .24)score in the control group ,and the difference was statistically significant (P＜0 .05) .The recovery rate of liver function in the 8th and 16th week was significantly lower than that in the first treatment group (P＜0 .05) ,and the serological conversion rate of HBV-DNA and the decrease of HBsAg titer in the control group were lower than those in the observation group (P＜0 . 05) .The difference was statistically significant (P＜0 .05) ,but there was no significant difference in the incidence of adverse reactions and drug resistance between the two groups (P＞0 .05) .Conclusion :Fuzheng Ganfu pill is effective in treating chronic viral hepatitis B with dampness and heat of liver and spleen .It can effectively improve the clinical symptoms ,inhibit the progress of the disease ,remove hepatitis B virus and improve the liver function of the patients . Improve the quality of life of patients .%目的:探究扶正肝复丸联合恩替卡韦治疗慢性乙型肝炎肝脾湿热证的临床疗效.方法:选取肝脾湿热证慢性乙型肝炎患者79例,随机分为对照组与观察组,对照组给予恩替卡韦治疗,观察组在对照组基础上服用扶正肝复丸,对比分析两组患者治疗前后临床疗效.结果:两组患者治疗16周后,观察组临床总有效率为94 .6%,对照组为71 .4%,观察组中医症候积分为(3 .05 ± 6 .16)分,对照组为(6 .26 ± 7 .24)分,经比较差异具有统计学意义( P＜0 .05) ;对照组第4周、第8周和第16周的肝功能恢复比率都明显低于初治组,差异具有统计学意义( P＜0 .05 ) ;对照组患者的HBV-DNA转阴率、HBeAg血清学转换率及 HBsAg 滴度下降50% 的患者均低于观察组,经比较两组差异具有统计学意义(P＜0 .05) ;两组患者不良反应发生情况及耐药性的比较差异无统计学意义(P＞0 .05) .结论:扶正肝复丸对于肝脾湿热型慢性乙型病毒性肝炎辅助治疗临床疗效显著,能有效改善患者的临床症状、抑制病情进展、清除乙肝病毒、改善患者肝功能、提高患者生活质量.