目的:分析清心益智汤对于改善阿尔茨海默病(AD)患者的生活质量、认知水平以及血清超氧化物歧化酶(SOD)、丙二醛(MDA)、总抗氧化能力(T-AOC)、氧化低密度脂蛋白(ox-LDL)表达水平的作用.方法:选取88例AD患者作为观察对象,分别纳入对照组与观察组,每组各44例;治疗两个疗程后评估临床疗效,分别于治疗前、治疗后,评估两组患者的生活质量、认知功能以及智能精神状态,同时观察两组患者血清SOD、MDA、T-AOC、ox-LDL表达水平的变化情况.结果:观察组总有效率81.82%,对照组总有效率63.64%,观察组疗效较对照组理想(P<0.05).治疗后两组ADAS-cog、ADL、M M SE均较前有所改善,组内对比差异有统计学意义(P<0.05);观察组较对照组良好,组间比较差异有统计学意义(P<0.05);治疗后两组SOD、MDA、T-AOC、ox-LDL均较前有所改善,组内比较差异有统计学意义(P<0.05);观察组较对照组良好,组间比较差异有统计学意义(P<0.05).结论:自拟清心益智汤能够有效改善AD患者的生活质量与认知水平,对于患者血清中SOD、MDA、T-AOC、ox-LDL的表达水平亦具有明确的改善作用.%Objective:To analyze the Qingxin Yizhi decoction in improving the quality of life of Alzheimer's disease(AD),the cognitive level and serum superoxide dismutase(SOD)patients,malondialdehyde(MDA),total antioxidant capacity(T-AOC),oxidized low density lipoprotein(ox-LDL)expression level role.Methods:88 cases of AD patients were treated as the observation objects were divided into control group and observation group,44 ca-ses in each group;to evaluate the clinical efficacy after two courses of treatment,respectively,before and after treat-ment,the two groups were evaluated the quality of life,cognitive function and mental state at the same time.Ob-serve two groups of patients with serum SOD,MDA,T-AOC,ox-LDL expression.Results:The total effective rate of the observation group was 81.82%,the total effective rate of the control group was 63.64%,and the effect of the observation group was better than the control group(P< 0.05).After treatment,the two groups of ADAS-cog, ADL and MMSE were improved compared with the previous group(P<0.05).The observation group was better than the control group.After treatment,the SOD,MDA,T-AOC and ox-LDL of the two groups were improved compared with those before,and was better than that in the control group(P<0.05).Conclusion:The Qingxin Yizhi decoction can effectively improve the quality of life and cognition level of AD patients,and has a definite im-provement effect on the expression level of SOD,MDA,T-AOC and ox-LDL in the serum of patients.
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