to eliminate the cause of diseases, prevent the occurrence of birth defects and improve the quality of newborns.Approach:Giving 1480 cases of women at childbearing age from pre-pregnancy or early stage of pregnancy a small dose of folic acid tablets"Serianen", as well as educational materials about the prevention of birth defects and eugenic trainings from January 2008 to December 2010.Results: the follow-up surveys on the 1480 cases of women after childbirth show, that non of their newborns has got birth defects such as neural tube defect or congenital heart disease, which means the preventive measures are 100% effective.Conclusion: Folic acid can effectively prevent birth defects such as neural tube defect and congenital heart disease. At the same time, the key of prevention of birth defects lies in taking primary preventive measures.% 目的：探讨叶酸补充在出生缺陷一级预防措施中的应用价值，预防出生缺陷的发生，提高人口出生素质。方法：2008年1月至2010年12月，让我区1480例准备生育的育龄女性从孕前及怀孕早期开始服用小剂量的叶酸增补剂斯利安，并为她们发放预防出生缺陷的宣传资料，对其进行分期优生培训。在1480例女性产后1个月至1年对其进行追踪调查。结果：调查结果显示，本组1480例女性所产小儿无一例发生神经管畸形及先天性心脏病等出生缺陷，预防出生缺陷的有效率为100%。结论：补充叶酸能有效地预防神经管畸形及先天性心脏病等出生缺陷。预防出生缺陷的关键在于采取一级预防措施。
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