（L）-2-氧代四氢噻唑-4-羧酸的合成研究及工艺改进

摘要

Using L-cysteine monohydrochloride and carbonochloridic acid phenyl ester as raw materi-als,reaction was carried out in an alkaline environment.After liquid separation,extraction,recrystalli-zation,obtained the reaction product.The structure of reaction product was characterized,and through continuous optimization,we determined the reaction process conditions which are as follows:the molar ratio of the materials n(carbonochloridic acid phenyl ester)∶n(L-cysteine monohydrochloride)is 1.6, the reaction temperature is 40 ℃,the reaction time is 2 h,the pH is 14,analysed the reaction mecha-nism.Finally,the optimum process conditions of the reaction is selected through experiment,comple-ted the synthesis of (L)-2-oxothiazo-lidine-4-carboxylic acid in the laboratory.%以 L-半胱氨酸盐酸盐和氯甲酸苯酯为主要原料在碱性环境中进行反应，经分液、萃取、重结晶，得到反应产物。对反应产物进行了结构表征，通过优化，确定了最优的反应工艺条件：n（氯甲酸苯酯）∶n（L-半胱氨酸盐酸盐）＝1．6，反应温度40℃，反应时间2 h，pH＝14，解析了反应机理，完成了（L）-2-氧代四氢噻唑-4-羧酸的实验室合成。