禽类 Ghrelin 研究进展

摘要

The peptide hormone ghrelin is secreted mainly by stomach,and is the only ligand that was found for growth hormone releasing hormone receptor to date.There are two forms of ghrelins exist in the body:N-octanoyl-modified ghrelin and des-acyl ghrelin,and this modification is essential for the activity of ghrelin.Ghrelin is widely distributed in various tissues in the body,with a variety of biological functions:regulating the release of growth hormone,food intaking,energy balance and so on.At present there are many reports related to the rodent animal ghrelin and the corresponding researches have been successful, but the study on poultry ghrelin lags behind,there are many aspects of poultry ghrelin to make clear.This paper made a simple summarize on the research of the poultry ghrelin about the molecular structure,tissue distribution and biological functions,hoping to provide reference for the study of ghrelin in poultry.%Ghrelin主要是由胃分泌的一种肽类激素，是迄今发现的生长激素促分泌素受体的唯一内源性配体。其在体内具有 N-端辛酰基化和 N-端去辛酰基化两种存在形式，N-末端辛酰基化对保证其生物活性是必需的。Ghrelin 广泛分布于机体各种组织中，具有调节生长激素释放、摄食和能量平衡等多种生物学功能。目前关于啮齿类动物 Ghrelin 的相关报道较多，研究已比较透彻，而对于禽类 Ghrelin 的研究则相对滞后，还有许多值得一步研究的地方。论文就近年来关于禽类 Ghrelin 的分子结构、组织分布、生物功能的研究做一概述，以期为禽类 Ghrelin 的研究提供参考。