猪细小病毒病毒样颗粒研究进展

摘要

Porcine parvovirus(PPV)is a main pathogen that causes serious reproductive disease of swine and death of piglets,and vaccination is one of the major measures.Due to bio-safety concern,the inactivated vac-cine was mainly used at home.Virus-like particles(VLPs)has the advantages of higher security and immu-nogenicity,it has become one of the hottest direction of virus vaccine research.Porcine parvovirus virus-like particles(PPV-VLPs)are empty capsid particles without PPV DNA,which are self-assembled by VP2 structural protein and are analogous to natural virus particles in morphology,and it has very strong bioac-tivity and immunogenicity.To provide the reference for the research of PPV-VLPs,this article reviewed im-mune mechanism of VLP-based vaccines and self-assembling of PPV-VLPs in the domestic and overseas.%猪细小病毒(PPV)是引起母猪繁殖障碍和仔猪死亡的主要病原，疫苗免疫预防是控制该病的主要手段。由于对生物安全的担心，目前国内使用的疫苗仍以灭活苗为主。病毒样颗粒(VLPs)疫苗以其安全性高、免疫原性好成为各类病毒疫苗研究的热门方向。猪细小病毒病毒样颗粒(PPV-VLPs)是不含 PPV DNA 的空衣壳结构，由 PPV VP2结构蛋白体外自行组装形成，形态上与天然病毒粒子相似，具有很强的免疫原性和生物学活性。论文就 VLPs 疫苗的免疫机制及 PPV-VLPs 的组装及其在国内外的研究进行综述，为 PPV- VLPs 研究提供参考。