血浆uPA、uPAR在乳腺癌分子亚型中的表达及临床意义

摘要

目的:探讨血浆uPA、uPAR在不同分子亚型乳腺癌中的表达水平及其对乳腺癌患者治疗、预后等的临床意义.方法:采用免疫组化ELISA方法测定的女性乳腺癌初治患者86例的血浆uPA、uPAR水平,所有患者均经组织病理学确诊,以患者的临床病理学资料提供的免疫组化结果为基础进行分子分型,结合二者进行分析.结果:血浆uPA在乳腺癌不同分子亚型中表达有统计学差异(P＜0.01),uPAR在乳腺癌不同分子亚型中表达有统计学差异(P＜0.05);乳腺癌患者血浆uPA和uPAR呈显著正相关(P＜0.01,Pearson相关系数r=0.735).结论:乳腺癌患者血浆uPA和uPAR的水平与分子亚型密切相关,他们和分子亚型联合,可能对乳腺癌个体化治疗及判定预后有指导意义.%Objective: To study the clinical significance of the plasma levels of uPA, uPAR in the molecular subtypes of breast carcinoma. Methods: Using ELISA method. Measuring the plasma levels of uPA, uPAR of 84 female inpatients with breast carcinoma, All patients visited a doctor for the first time. Results: The plasma levels of uPA, uPAR in the molecular subtypes of breast carcinoma are different (P<0.05). The plasma levels of uPA have a hingh relation with uPAR in breast carcinoma (P<0.01,r=0.735.) Conclusion: The plasma levels of uPA, uPAR in the patients with breast carcinoma were corelated with the molecular subtypes. Combined the detection of the plasma levels of uPA, uPAR whith the molecular subtypes may heplefull for the individualized treatment and estimating prognosis.