MAPKs信号通路在动脉粥样硬化发生发展中的调控作用

摘要

Mitogen-activated protein kinase (MAPK) signal transduction pathways are ubiquitous and highly evolutionarily conserved mechanisms of eukaryotic cell regulation,controling essential processes in all eukaryotic cells,including cell proliferation,development,differentiation,apoptosis and inflammation reaction.MAPK signaling cascades likely play an important role in the pathogenesis of cardiac and vascular disease.Atherosclerosis is a chronic disease of the arterial wall,and a leading cause of death and loss of productive life years worldwide,while its molecular mechanism of development is unclear.Recently,more attention is paid to its functions in the atherosclerotic development.%丝裂原激活蛋白激酶(mitogen-activated protein kinases,MAPKs)信号通路是生物体内重要的信号传导通路,其主要参与调控细胞的增殖、生长、分化、凋亡和炎症反应等多种生理病理过程.MAPKs信号通路在多种心血管疾病的病理过程中起着重要调控作用.动脉粥样硬化(athrosclerosis,AS)所致的各种急重症严重危害人类的健康,发病率呈逐年上升的趋势,但是动脉粥样硬化发生发展的分子机制尚不完全清楚.近年来,MAPKs信号通路在动脉粥样硬化(athrosclerosis,AS)的发生发展中的作用已成为是研究的热点.