康复新液联合胸腺五肽局部应用对口腔溃疡的疗效及对血清TNF-α、IL-6、SOD、SIgA、IgG的影响

摘要

目的:研究康复新液联合胸腺五肽局部应用对口腔溃疡的疗效及对血清肿瘤坏死因子-0 (tumor necrosis factor-α,TNF-α)、白介素-6 (Interleukin,Ⅱ-6)、超氧化物歧化酶(Superoxide dismutase,SOD)、唾液分泌型免疫球蛋白(secretory im-munoglobulin A,SIgA)、免疫球蛋白(immunoglobulin,IgG)的影响.方法:选取2014年12月至2016年12月我院收治的86例口腔溃疡患者,按照随机数表法分为康复新液组(n=43)和联合治疗组(n=43).康复新液组患者采取康复新液治疗,联合治疗组则采取康复新液联合胸腺五肽局部应用治疗.观察并比较两组患者临床治疗效果、症状改善情况、疼痛缓解时间和溃疡愈合时间、血清TNF-α、IL-6、SOD水平变化情况、SIgA和IgG水平以及不良反应和复发情况.结果:与治疗前比较,两组患者治疗72 h后疼痛程度均明显改善,溃疡直径显著缩小,总积分明显下降,总积分下降指数显著攀升(P＜0.05);血清TNF-α、IL-6水平明显下降,血清SOD水平明显升高(P＜ 0.05).与康复新液组患者相比,联合治疗组患者总有效率明显升高(P＜0.05),疼痛程度、溃疡直径、总积分、总积分下降指数改善情况更优(P＜0.05),缓解时间和溃疡愈合时间明显缩短(P＜0.05),血清WNF-α、IL-6水平下降和血清SOD水平升高程度更明显(P＜0.05).两组患者治疗后SIgA水平较治疗前明显升高,IgG水平较治疗前显著降低,且联合治疗组以上指标的改善情况显著优于康复新液组(P＜0.05),复发率明显较低(P＜0.05).结论:康复新液联合胸腺五肽局部应用治疗口腔溃疡临床治疗效果明显优于康复新液单药治疗,可有效缓解疼痛、减轻患者相关症状、加速愈合,其机制可能与降低血清TNF-α、IL-6水平及提高血清SOD水平有关.%Objective:To study the effect of Kangfuxin liquid combined with topical application of thymopentin on the oral ulcer and the serum TNF-α,IL-6,SOD,SIgA and IgG levels.Methods:86 cases with oral ulcer fiom December 2014 to December 2016 were selected and divided into the Kangfuxin Liquid group (n=39) and the combination therapy group (n=39) according to the random number table.Kangfuxin Liquid group was treated by Kangfuxin Liquid,ewhile combination therapy group was given thymopentin topical on the basis of Kangfuxin Liquid.The clinical effect,improvement of symptoms,relief time of pain and ulcer healing time,serum TNF-α,IL-6,SOD levels,SIgA and IgG levels and the incidence of adverse reactions and relapse were compared between two groups.Results:At 72h aRer treatment,compared with before treatment,the pain levels of both groups were significantly improved,ulcer diameters were significantly reduced,total scores were significantly decreased,the total score drop index were significantly decreased (P＜0.05).The relief time of pain and ulcer healing time of Kangfuxin Liquid group were longer than those of the combined treatment group (P＜0.05);the serum TNF-α and IL-6 levels were significantly decreased,serum SOD levels were significantly increased (P＜0.05).Compared with the Kangfuxin Liquid group,the total effective rate of combined treatment group was significantly higher (P＜0.05),the improvement of pain level,ulcer diameter,total score and total score drop index were better (P＜0.05),the levels of serum TNF-α and IL-6 were significantly decreased and the level of serum SOD was significantly increased (P＜0.05);the SIgA levels in both groups were significantly higher than those before treatment,the levels of IgG were significantly decreased than those before treatment,which were improved significantly better in the combined treatment group than those of the Kangfuxin Liquid group (P＜0.05);The recurrence rate was significantly lower in the combined treatment group (P＜0.05).Conclusion:The combination of Kangfuxin liquid and thymopentin was more effective than Kangfuxin liquid single used in the treatment of oral ulcer,it could effectively relieving the pain and symptoms,accelerat the healing,which might be related to the decrease of serum TNF-α,IL-6 levels and increase of serum SOD levels.