心可舒片治疗冠心病患者PCI术后焦虑的疗效及对生活质量的影响

摘要

目的:探讨心可舒片治疗冠心病(CAD)患者经皮冠状动脉介入(PCI)术后焦虑的疗效及对生活质量的影响.方法:选择2015年1月～2017年1月我院心内科收治的68例行PCI术后合并焦虑的CAD患者并将其随机分为治疗组(n=34)、对照组(n=34).对照组给予常规药物治疗,治疗组在此基础上给予心可舒片,4片/次,3次/d,治疗周期为3个月.比较两组患者治疗前后血液流变学指标、焦虑症状、生活质量的变化.结果:治疗3个月后,治疗组患者全血黏度、血浆黏度、红细胞压积及血小板聚集率均较治疗前显著下降,且均明显低于对照组(P＜0.05);治疗1个月后,两组HAMA评分均较治疗前明显减低(P＜0.05),而两组间比较差异无统计学意义(P＞0.05);治疗3个月后,治疗组HAMA评分明显低于对照组(P＜0.05);治疗l、3个月后,两组WHOQOL-BREF各维度评分均较治疗前明显升高(P＜0.05),且治疗组心理、社会关系维度评分显著高于对照组(P＜0.05).结论:心可舒片可改善CAD患者PCI术后合并焦虑患者的血液流变学,缓解焦虑症状,提高患者的生活质量.%Objective:To explore the clinical efficacy of Xinkeshu Tablets in the treatment of coronary heart disease (CAD) patients with depression after percutaneous coronary intervention (PCI) and effect on the quality of life (QOL).Methods:68 cases of patients with CAD and depression after PCI were randomly divided into the treatment group (n=34) and the control group (n=34).The control group was given routine drug treatment,while the treatment group was given Xinkeshu tablets for 4 tablets each time,3 times a day on the basis of control group.The treatment course was 3 months.The changes of hemorheology indexes,anxiety symptoms,QOL after PCI were compared between two groups.Results:After treatment,the blood viscosity,plasma viscosity,hematokrit and platelet aggregation rate were significantly lower than those before treatment.At 1 month after treatment,the HAMA score in both groups were all remarkably reduced (P＜0.05),and there was no significant difference on the the HAMD score between two groups (P＞0.05).At 3 months after treatment,the HAMA score in treatment group was significantly reduced than that in the control group (P＜0.05).At 1,3 months after treatment,the WHOQOL-BREF score of each dimension were significantly increased than those before treatment(P＜0.05),and the psychological,social relations dimension scores in treatment group were significantly higher than those in the control group(P＜0.05).Conclusions:Xinkeshu tablets can improve the hemorheology,reduce the anxiety symptoms,improve the QOL in the treatment of CAD patients with depression after PCI.