阿托伐他汀抗心肌缺血再灌注损伤的作用机制研究

摘要

目的:研究阿托伐他汀(ATV)在对心肌缺血再灌注损伤(IRI)的保护效应中,两种ATP依赖的K+(KATP)通道的作用.方法:将32只实验家兔随机分为对照组、ATV组、ATV+5-HD(A1组)、ATV+HMR1883(A2组).通过结扎和放松冠状动脉左前降支,分别进行30 min的心肌缺血和再灌注.实验中持续监测左室舒张末期压(LVEDP)、左心室压最大变化速率(±dp/dtmax)的变化.结果:与对照组相比:ATV组及A2组各项心功能指标在再灌注30 min后明显改善(P＜0.05),而A1组差异无显著性(P＞0.05).结论:ATV的抗心肌IRI保护效应可能与线粒体KATP通道有关.%Objective:To observe the role of two ATP-sensitive K+channels in the protective effect of atorvastatin(ATV)on myocardial ischemia-reperfusion injury(IRI).Methods:Thirty-two rabbits were randomly divided into four groups:control group,ATV group,ATV+5-HD(A1),ATV+HMR1883(A2).All rabbis were subjected to 30 min ischemia and 30 min reperfusion.The max rate of rise of left ventricular pressure(±dp/dtmax) and left ventricular end-diastolic pressure(LVEDP) were detected during the experiment.Results:Compared with the control group,the indexes of heart function were improved significantly(P＜0.05) in the ATV group and the A2 group.And there was no statistically significant between the control group and A1 group(P＞0.05).Conclusion:The mitochondrial KATP channel is likely involved in the protective mechanism that against myocardial IRI in rabbits of ATV.