血清PSA联合PAP检测提高前列腺癌诊断率的临床应用价值探讨〔1〕

摘要

目的：探讨血清前列腺特异性抗原（ PSA）联合酸性磷酸酶（ PAP）检测对前列腺癌患者的诊断价值。方法：采用化学发光分析法对96例诊断为前列腺癌的患者、48例前列腺增生患者以及48例正常男性的血清PSA，PAP进行测定。结果：PSA检出前列腺癌的灵敏性为93.75％，特异性为72.38％；PAP对前列腺癌的灵敏性为70.83％，特异性为89.11％。结论：PSA对前列腺癌的疗效监测和筛选诊断有较大的价值，而PAP不适合用于前列腺癌的筛检，PSA可以完全替代PAP对前列腺癌的疗效和预后的监视作用；但PSA联合PAP检测能够有效提高前列腺癌的诊断率以及鉴别前列腺癌与前列腺增生的准确性，具有较大的临床应用价值。%Objective:To investigate the serum prostate specific antigen(PSA)and acid phosphatase(PAP)in diagnosis of prostate cancer. Methods:To mensurate serum PSA,PAP of 96 cases diagnosed with prostate cancer,48 patients with benign prostatic hyperplasia and 48 cases of normalmale. Results:The sensitivity of PSA detection of prostate cancer was 93. 75%,the specificity was 72. 38%. The sensitivity of PAP in prostate cancer was 70. 83%,the specificity was 89. 11%. Conclusion:PSA has great value for prostate cancer screening and monitoring and diagnosis,PAP is not suitable for screening for prostate canc-er,monitoring PSA can completely replace the curative effect and prognosis of PAP on prostate cancer. But the detection of PSA combined with PAP can improve the diagnosis rate of prostate cancer and diagnosis of prostate cancer and benign prostatic hy-perplasia,is of great clinical value.