目的 研究2次/d预混人胰岛素70/30治疗血糖控制欠佳的2型糖尿病患者转用优泌乐25联合二甲双胍治疗的有效性和安全性.方法 2次/d注射预混人胰岛素70/30(联合或不联合口服降糖药)血糖控制欠佳的2型糖尿病患者54例,换用优泌乐25联合二甲双胍治疗.在治疗开始及12用分别记录空腹血糖、餐后2h血糖、HbAlc(糖化血红蛋白)、体重指数及胰岛素剂量.结果 治疗12周后,空腹血糖、餐后2h血糖、HbAlc、体重指数及胰岛素剂量均较基线水平显著下降.出现低血糖12例.结论 应用预混人胰岛素70/30治疗血糖控制欠佳的2型糖尿病患者,转用优泌乐25联合二甲双胍治疗后,其血糖可得到安全、有效的控制.%Objective To study the efficacy and safety of insulin mix lispro 75/25 combined with metformin on inadequately glycemia control patients with type 2 diabetes who have been treated with premixed insulin regimen. Methods 54 patients with type 2 diabetes mellitus taking premixed insulin were switch to insulin mix lispro 75/25 plus metformin due to the inadequate glycemia control. The fasting blood glucose( FBG) ,2-h post prandial blood glu-cose(2-hPBG) ,glycosylated haemoglobin( HbA,c) ,body mass index(BMI) .insulin dosage were measured at the start and after a 12-week observation period. Results The FBG,2-hPBG and HbAIc improved significantly. Insulin dosage and BMI decreased. The hypoglycemia was found in 12 cases. Conclusion After given insulin mix lispro 75/25 combined with metformin, the blood sugar of the inadequately glycemia control patients with type 2 diabetes who have been treated with premixed insulin regimen can be controlled safely and effectively.
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