熊去氧胆酸治疗早产儿胃肠外营养相关性胆汁淤积症

摘要

目的 探讨熊去氧胆酸(UDCA)用于早产儿胃肠外营养相关性胆汁淤积(PNAC)的疗效.方法 收集2008年6月-2011年12月在我院出生的PNAC早产儿共40例,随机分为对照组20例,男12例,女8例;治疗组20例,男11例,女9例.比较两组患儿的疗效及相关指标改善情况.结果 治疗组治疗第10、20天的总胆红素(TB)、结合胆红素(DB)、总胆汁酸(TBA)明显低于对照组(P<0.05);患儿治疗前后肝、肾功检查显示未出现药物相关性不良反应.结论 熊去氧胆酸治疗早产儿胃肠外营养相关性胆汁淤积症安全、有效,值得临床推荐使用.%Objective To study the curative effect of ursodeoxycholic acid used for premature parenteral nutrition associated cholestasis ( PNAC ). Methods 40 premature children with PNAC born in our hospital from June 2008 to December 2011 were randomly divided into control group( 12 male,8 female )and treatment group( 11 male,9 female ),20 cases in each group. The improvement of relevant indicators of children's curative effect was observed. Results At 10th and 20th day,the total bilirubin ( TB ),direct bilirubin ( DB ),total bile acid ( TBA )of treatment group were significant lower than those of control group ( P <0. 05 ). The liver and kidney function tests showed no drug-related adverse reaction. Conclusion Ursodeoxycholic acid treatment for premature PNAC is safe and effective, and it is worthy of clinical use.