固尔苏不同给药方法治疗新生儿呼吸窘迫综合征的疗效分析

摘要

Objective To investigate the clinical effect of different methods of curosurf treatment for neonatal respiratory distress syndrome (NRDS).Methods 92 cases of NRDS admitted to our hospital from January 2009 to October 2012 were randomly divided into study group and control group,46 cases in each group,the two groups were treated with mechanical ventilation and curosurf treatment,study group used a modified supine positive pressure closed endotracheal to injection administration;control group used multi-positional endotracheal administration.Results The PaO2,PaCO2,pH of the two groups had no significant difference before treatment(P ＞ 0.05).The PaO2 of study group was significantly higher than that of control group,and the PaCO2 was significantly lower(P ＜ 0.05).The duration of mechanical ventilation,oxygen therapy,and hospitalization time of study grup were shorter than those of control group (P ＜ 0.05).The medication oxygen desaturation,drug reflux,the endotracheal intubation detached incidence of study group were significantly lower than those of control group (P ＜ 0.01).Conclusion Curosurf sit-bit positive pressure closed endotracheal administration can effectively reduce the medication complications,improve the effect on NRDS,it is simple and effective.%目的 探讨固尔苏不同给药方式治疗新生儿呼吸窘迫综合征(NR DS)的临床效果.方法 将我院2009年1月至2012年10月收治的NRDS患儿92例随机分为研究组和对照组,每组46例.两组均给予机械通气同时应用固尔苏治疗,研究组采用改良仰卧位正压密闭气管内注入给药；对照组采用多体位气管内给药.观察两组治疗前后血气变化,比较两组患儿机械通气时间、氧疗时间、住院时间及并发症发生情况.结果 治疗前两组患儿PaO2、PaCO2、pH比较差异无统计学意义(P＞0.05)；治疗后研究组PaO2明显高于对照组,PaCO2明显低于对照组(P＜0.05).研究组患儿机械通气时间、氧疗时间及住院时间均较对照组短(P＜0.05).研究组用药时血氧饱和度下降、药物反流、气管插管脱管发生率明显低于对照组(P＜0.01).结论 固尔苏仰卧位正压密闭气管内给药可以有效降低用药并发症,提高NRDS治疗效果,其操作简便,疗效确切.