阿托伐他汀在冠心病治疗中的抗炎作用研究

摘要

目的 探讨阿托伐他汀在治疗冠心病(CHD)中的抗炎作用.方法 2010年1月至2011年12月我院门诊及住院冠心病患者120例,随机分为2组:对照组和治疗组,每组60例.两组均按CHD伴高脂血症常规内科治疗,治疗组加用阿托伐他汀20 mg,1次/d,口服.比较两组患者血脂及血清C反应蛋白、一氧化氮等水平变化及心绞痛、心律失常发作次数,心力衰竭、脑卒中事件及不良反应等情况,并对比其疗效.结果 治疗8周后,治疗组总胆固醇、三酰甘油、低密度脂蛋白、C反应蛋白等均较治疗前显著下降,高密度脂蛋白及一氧化氮均显著升高,治疗前后比较,差异有统计学意义(P＜0.05),而对照组治疗前后上述指标比较差异无统计学意义(P＞0.05).治疗期间发生心绞痛、心律失常、心力衰竭加重及脑卒中例数,治疗组显著低于对照组(P＜0.05).两组不良反应例数比较差异无统计学意义.结论 阿托伐他汀能通过抗炎作用治疗冠心病合并高脂血症,且不良反应少.%Objective To investigate the anti-inflammatory effect of atorvastatin on coronary heart disease.Methods 120 patients with coronary heart disease in our hospital from January 2010 to December 2011 were randomly divided into two group:treatment group and control group,60 cases in each group.All patients were given conventional treatment,and the treatment group was added with atorvastatin 20 mg,once daily.The lipids and serum C-reactive protein,nitric oxide level changes and angina,arrhythmias number of attacks,heart failure and stroke events and adverse reactions of the two groups were compared.Results After 8 weeks of treatment,the total cholesterol,triglycerides,low-density lipoprotein,C-reactive protein of treatment group were significantly lower,and the high-density lipoprotein and nitric oxide were significantly higher(P ＜ 0.05),the above indicators of the control group showed no significant difference(P ＞ 0.05).During the treatment,the angina,arrhythmias,worsening heart failure and the number of stroke in treatment group were significantly lower than those of control group (P ＜ 0.05).There was nosignificant difference in the incidence of adverse reactions between the two groups.Conclusion Atorvastatin could treat coronary heart disease and hyperlipidemia by anti-inflammatory effect between the two few adverse reactions.