正交试验优选五倍子软膏处方

摘要

Objective To optimize the best prescription of gallnut extract ointment. Methods With appearance and stability of ointment as index, orthogonal design experiment was carried out, with beeswax amount, the amount of emulsifier and the major adding method as the variables, the Theological parameters were determined. Results Optimized prescription was A2B3C2 ,which including 2% beeswax,4% span-80,and the way was to put the drug into oil phase. Conclusion The ointment formulation is reasonable, and the preparation has good stability.%目的 优选五倍子软膏剂的最佳处方.方法 以软膏的外观性状、稳定性为考察指标,采用正交设计法进行实验,以蜂蜡用量、乳化剂用量、主要的加入方式为可变因素,并测定流变学参数.结果 优化处方A2B3C2,即蜂蜡2%,span-80 4%,加药方式为药物加入油相.结论 该软膏处方设计合理,制剂稳定性较好.