普伐他汀相关肌病不良反应的研究进展

摘要

目的：对普伐他汀导致相关肌病不良反应的最新研究进展进行简要综述，探讨普伐他汀在临床上的合理应用及肌病不良反应的防治措施。方法检索EMbase、万方数据库、中国生物医学文献数据库中相关文献，结合临床，进行综合分析。结果普伐他汀可致相关性肌病、疲倦和劳力性疲劳等不良反应。结论制定普伐他汀的合理用药方案，最大限度地发挥其降脂疗效，减少肌病等不良反应的发生。%Objective To briefly review the latest research progress about adverse reactions of pravastatin re-lated myopathy,investigate the reasonable application of pravastatin in the clinical and prevention measures of myopa-thy adverse reactions. Methods The EMbase,Wanfang database,China biomedical literature database of relevant liter-atures were retrieved,and the results were comprehensively analyzed combined with clinical. Results Pravastatin can cause related myopathy,tired and exertional fatigue and other adverse reactions. Conclusion Rational use of pravasta-tin can maximize its lipid-lowering effect,reduce the occurrence of adverse reactions such as myopathy.