乙酰唑胺对慢性阻塞性肺疾病无创通气酸碱平衡的影响

摘要

目的：探讨乙酰唑胺对慢性阻塞性肺疾病( COPD)无创通气患者酸碱平衡的影响。方法选择2010-2014年急性加重期COPD患者70例,分为乙酰唑胺治疗组(研究组,38例)和非乙酰唑胺治疗组(对照组,32例),测定患者服用乙酰唑胺0、24、48 h后的PaCO2、HCO3-,以及血清、尿液的pH值。结果研究组患者治疗后24、48 h的PaCO2、HCO3-、血清pH值均降低(P0．05),对照组仅在治疗48 h时HCO3-降低,尿pH升高(P0. 05);the HCO3- in control group significantly decreased,while the urinary pH value in-creased at 48 h after treatment. The ventilation length of experiment group was significantly shorter than that of control group[(5. 53 ± 1. 72) d vs. (18. 81 ± 4. 08) d,t=17. 197,P<0. 001],but there was no significant difference in the hospitalization length between the two groups (t=0. 418,P=0. 877). Conclusion Acetazolamide can effectively im-prove the PaCO2 ,HCO3- and the pH value of serum and urine in the patients with COPD,and oral administration of ac-etazolamide for two consecutive days can significantly shorten the noninvasive ventilation time.