老年食管癌患者放疗疗效及相关临床因素分析

摘要

目的 探讨老年食管癌患者放射治疗的近远期疗效及其影响因素.方法 回顾性分析哈尔滨医科大学附属第三医院70例自2001年1月-2007年12月间以放疗为主要治疗手段,年龄≥70岁的老年食管癌患者的近期疗效,1、2、3年生存率及其相关临床因素和毒副反应的耐受情况.结果 放疗后总有效率为88.5%.1、2、3年总生存率及无病生存率分别是62.28%和10.80%、27.51%和7.20%、13.89%和3.40%.单因素及多因素分析显示,影响生存期的主要因素为病变的长度、治疗前转移情况(P＜0.05).急性放射性肺反应、急性放射性食管反应及骨髓抑制发生率分别为24.3%、64.3%和48.6%.结论 放射治疗老年食管癌患者近期疗效显著,耐受性好;影响其生存期的主要因素是治疗前病灶长度及是否有转移.%Objective To analyze the outcome and influencing factors of radiotherapy in elderly esopha-geal cancer patients. Methods Seventy patients over 70 years with esophageal cancer were treated mainly by radiotherapy from January 2001 to December 2007. Recent effect,the 1^2^3 year survival rate and it's influencing factors, toxic side effects were analyzed retrospectively. Results After radiotherapy for 70 patients with esophageal cancer,the total effect rate was 88. 5% ( 62/70 ). The K2^3 year survival rate and disease free survival is 62. 28% and 10. 80% ^27. 51% and 7. 20% 43. 89% and 3.40% .respectively. Using univariate and multivari-ate analysis, focal length and whether there is metastasis were significantly associated with the survival rate. Conclusion Radiotherapy for elderly patients with esophageal cancer had significant effect and well tolerated; focal length and whether there is metastasis were the main survival - related prognostic factors.