胃泌素与 Reg 基因在胃癌组织中的表达及临床意义的研究进展

摘要

随着研究的深入，胃泌素（ Gastrin）及其受体与Reg基因家族，尤其是RegⅠ和RegⅣ与消化系统肿瘤的生物学行为、发生发展和预后有密切的关系，其中后者可能起到类似癌基因的作用。所以胃泌素联合Reg基因的检测可能有助于早期胃癌的诊断，并为胃癌的防治提供新的靶点。本文就胃泌素及其受体与Reg基因在胃癌组织中的表达及临床意义的相关研究进展做一综述。%With the development of the research ,gastrin secrete element and Reg gene families ,especial-ly the RegⅠand RegⅣ have a close relationship in biological behavior ,development and progress of digestive system tumor,the latter maybe play a role of oncogenes .So combination of gastrin with REG gene may contribute to the diagnosis of early gastric cancer ,and provides new target for prevention of gastric cancer .The present review summarized the related research progress on expression as well as clinical significant of gastrin and Reg gene in gastric cancer tissue .