胰岛素样生长因子结合蛋白-2与肺癌关系的研究进展

摘要

胰岛素样生长因子结合蛋白-2（Insulin like growth factor binding protein -2，IGFBP-2）作为肺癌高敏感的生物标记物，在肺癌的发生、发展及治疗中扮演重要的角色。研究显示其通过激活IGF1R及整合素介导的信号转导通路促进肿瘤的进展；且目前发现其在肺癌的靶向治疗中也起着重要的作用，有望成为肺癌治疗的新靶点，因此本文就IGFBP-2与肺癌的关系进行总结及综述。%As a high sensitive biomarker of lung cancer ,IGFBP2 plays an important role in the occur-rence,development and treatment of lung cancer .Studies have showed that it promotes tumor progression by acti-vating the IGF1R and integrin mediated signal transduction pathway .Recent researches have demonstrated that it participates in targeted therapy of lung cancer ,which may become a new target for the treatment of lung cancer . This paper makes a review on the relationship between IGFBP 2 and lung cancer .