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Association Between Insulin-Like Growth Factor Binding Protein-3 Promoter Polymorphism of -1590 C>A and Lung Cancer Susceptibility in a Chinese Han Population

机译:胰岛素样生长因子结合蛋白-3启动子多态性-1590 C> A多态性与中国汉族人群肺癌易感性的关系

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摘要

Recent studies have identified a negative correlation between serum levels of insulin-like growth factor binding protein-3 (IGFBP-3) and the risk of lung cancer. In this study, polymorphisms present at the -1590 site of the IGFBP-3 promoter were evaluated in relation to lung cancer risk in a Chinese Han population. A total of 248 nonsmall cell lung cancer (NSCLC) cases and 29 small cell lung cancer cases were compared with 252 matched, healthy controls. Polymerase chain reaction-based restriction fragment length polymorphism assays were used to detect polymorphisms present. The A/A genotype and an A allele were both associated with an increased risk of NSCLC after being adjusted for age and gender (adjusted odds ratio = 2.296, 95% confidence interval = 1.133-4.655; and adjusted odds ratio = 1.390, 95% confidence interval = 1.042-1.854, respectively). In conclusion, the A/A genotype and A allele of the IGFBP-3 promoter -1590 site may represent a genetic risk factor for NSCLC, with the A/A genotype being associated with a higher risk for squamous cell carcinoma than adenocarcinoma.
机译:最近的研究发现,血清胰岛素样生长因子结合蛋白3(IGFBP-3)的水平与患肺癌的风险之间呈负相关。在这项研究中,IGFBP-3启动子在-1590位点存在的多态性与中国汉族人群患肺癌的风险有关。将总共​​248例非小细胞肺癌(NSCLC)病例和29例小细胞肺癌病例与252名匹配的健康对照组进行了比较。基于聚合酶链反应的限制性片段长度多态性分析用于检测存在的多态性。经过年龄和性别调整后,A / A基因型和A等位基因均与NSCLC风险增加相关(调整后的优势比= 2.296,95%置信区间= 1.133-4.655;调整后的优势比= 1.390,95%置信区间分别为1.042-1.854)。总之,IGFBP-3启动子-1590位点的A / A基因型和A等位基因可能代表了NSCLC的遗传危险因素,与腺癌相比,A / A基因型与鳞状细胞癌的风险更高。

著录项

  • 来源
    《Genetic Testing》 |2011年第5期|p.301-306|共6页
  • 作者单位

    Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430023 China;

    Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430023 China;

    Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430023 China;

    Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430023 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 13:19:30

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