RECK 蛋白低表达示乳腺癌预后不良

摘要

目的：探讨RECK蛋白表达与乳腺癌患者预后的关系。方法应用免疫组织化学染色法检测148例乳腺癌标本中RECK蛋白的表达，分析RECK表达与乳腺癌临床病理因素及预后的关系。结果 RECK蛋白阴性乳腺癌患者无病生存时间及5年总生存时间显著差于RECK阳性者。腋下淋巴结阴性乳腺癌患者，RECK阴性患者与阳性患者比较其预后显著不良。 Cox多因素分析显示RECK阴性是乳腺癌预后不良的独立危险因素。结论对于乳腺癌患者，RECK蛋白表达缺失提示预后不良，RECK蛋白可成为判断乳腺癌预后的重要指标之一。%Objecive To explore the significance of RECK expression in breast cancer .Methods Im-munohistochemical staining was used to analyze RECK expression levels in patients with breast cancer .We com-pared these data with the clinicopathological features of these patients .Rseults Breast cancer patients with nega-tive RECK expression had significantly lower DFS and 5-year survival rates than patients with positive RECK expression.In addition,for node-negative breast cancer ,negative RECK expression indicated markedly unfavor -able survival rate than positive arm .Multivariate analysis further confirmed that RECK expression was an inde -pendent prognostic factor for patients with breast cancer .Conclusion The loss of RECK expression indicates un-favorable survival rate for patients with breast cancer .RECK expression is a new ,important risk factor for recur-rence in breast cancer .