大黄川芎汤对严重脓毒症患者血乳酸及乳酸清除率的影响

摘要

目的 探讨大黄川芎汤对严重脓毒症患者血乳酸及乳酸清除率的影响.方法 按照随机数字表的分组方法将90例严重脓毒症患者分成观察组和对照组,每组45例.对照组患者接受脓毒症集束化治疗,观察组在对照组的基础上给予大黄川芎汤鼻饲. 比较两组患者治疗后6 h、24 h及48 h的APCHEⅡ评分及治疗后6 h及24 h的血乳酸水平, 计算6 h及24 h乳酸清除率. 结果 观察组治疗后6 h、24 h及48 h的APCHEⅡ评分均低于对照组,两组比较差异均有统计学意义(P<0.05). 观察组治疗后6 h、24 h血乳酸水平及乳酸清除率均优于对照组,两组比较差异均有统计学意义(P<0.05). 结论 大黄川芎汤可改善严重脓毒症患者急性生理紊乱状况,能有效降低患者血乳酸水平及乳酸清除率,对严重脓毒症患者具有较好的临床应用价值.%Objective To investigate the effects of Dahuang Chuanxiong decoction on blood lactate and lactate clearance in patients with severe sepsis. Methods According to the grouping method of random number table,90 cases of severe sepsis patients were divided into observation group and control group,45 cases in each group. The control group were received sepsis bundle therapy,the observation group were received nasal feeding Dahuang Chuanxiong decoction. The APCHE score at 6 h,24 h and 48 h and the blood lactic acid level and lactate clearance rate after 6 h and 24 h treatment of the two groups were compared. Results The APCHE score at 6 h,24 h and 48 h in the observation group were all better than those in the control group(P<0.05). The blood lactic acid level and lactate clearance rate after 6 h and 24 h treatment in the observation group were all better than those in the control group (P<0.05). Conclusion Dahuang Chuanxiong decoction could improve acute physiology disorder in patients with severe sepsis,can effectively reduce the blood lactic acid level and lactate clearance rate,which has better clinical value for patients with severe sepsis.