盐酸纳洛酮联合醒脑静注射液治疗急性酒精中毒的临床疗效及其对血清β-内啡肽、丙二醛水平的影响

摘要

Objective To observe the clinical effect of naloxone hydrochloride combined with xingnaojing injection on acute alcoholism,to investigate the impact on the serum levels of β-endorphin and malondialdehyde.Methods A total of 104 patients with acute alcoholism were selected in the First Hospital of Changsha from 2015 to 2016,and they were divided into control group and observation group according to random number table,each of 52 cases.Based on symptomatic treatment,patients of control group received naloxone hydrochloride,while patients of observation group received naloxone hydrochloride combined with xingnaojing injection.Clinical effect,disappearance time of clinical symptoms,serum levels of β-endorphin and malondialdehyde before treatment and after 12 hours of treatment were compared between the two groups,and incidence of adverse reactions was observed during the treatment.Results No statistically significant differences of clinical effect was found between the two groups (P ＞ 0.05).Disappearance time of consciousness disturbance,hypertension,answering questions independently and walking independently of observation group were statistically significantly shorter than those of control group (P＜0.05).No statistically significant differences of serum level of β-endorphin or malondialdehyde was found between the two groups before treatment (P ＞ 0.05),while serum levels of β-endorphin and malondialdehyde of observation group were statistically significantly lower than those of control group after treatment (P ＜ 0.05).No statistically significant differences of incidence of adverse reactions was found between the two groups during the treatment (P ＞ 0.05).Conclusion Naloxone hydrochloride combined with xingnaojing injection has certain clinical effect in treating acute alcoholism,can effectively shorten the disappearance time of clinical symptoms,reduce the serum levels of β-endorphin and malondialdehyde,with relatively high safety.%目的 观察盐酸纳洛酮联合醒脑静注射液治疗急性酒精中毒的临床疗效,并探讨其对血清β-内啡肽、丙二醛水平的影响.方法 选取2015-2016年长沙市第一医院收治的急性酒精中毒患者104例,采用随机数字表法分为对照组与观察组,每组52例.在对症治疗基础上,对照组患者予以盐酸纳洛酮治疗,观察组患者予以盐酸纳洛酮联合醒脑静注射液治疗.比较两组患者临床疗效、临床症状消失时间及治疗前和治疗后12h血清β-内啡肽、丙二醛水平,并观察两组患者治疗期间不良反应发生情况.结果 两组患者临床疗效比较,差异无统计学意义(P＞0.05).观察组患者意识障碍消失时间、高血压消失时间、不能独立答题消失时间、不能独立行走消失时间短于对照组(P＜0.05).治疗前两组患者血清β-内啡肽、丙二醛水平比较,差异无统计学意义(P＞0.05);治疗后12h观察组患者血清β-内啡肽、丙二醛水平低于对照组(P＜0.05).两组患者治疗期间不良反应发生率比较,差异无统计学意义(P＞0.05).结论 盐酸纳洛酮联合醒脑静注射液治疗急性酒精中毒的临床疗效确切,可有效缩短患者临床症状消失时间,降低血清β-内啡肽、丙二醛水平,且安全性较高.