急性纤维素性机化性肺炎一例报道并文献复习

摘要

急性纤维素性机化性肺炎(AFOP)是近年新发现的一种罕见的肺炎病理类型,镜下表现以气腔内大量纤维素样物质沉积为特征,以肺泡间隔略增宽为典型病理表现,常伴有淋巴细胞和浆细胞浸润,肺泡腔内可见成纤维细胞呈息肉状延伸(机化)伴纤维素样物质红染.目前,国内外关于AFOP的病例报道较少,而由于其临床表现缺乏特异性,因此APOP能否作为独立诊断尚存在争议.本文报道了1例经气管镜肺组织活检诊断为AFOP的患者,并结合文献对AFOP的临床表现、病理特点、治疗及预后等进行复习,以期提高临床医生对该病的认识.%Acute fibrinous and organizing pneumonia(AFOP) is a new rare pathological type,mainly performed as large fibrinoid substance deposition under microscope,slightly widened alveolar septum is the typical pathological feature,usually accompanied with lymphocyte and plasmocyte infiltration,polypoid extension(organization)of fibroblast and red-dye fibrinoid substance.At present,case reports of AFOP is rare in domestic and foreign,because of lack of specificity of clinical manifestations,APOP can be independent diagnosis or not is still controversial.This paper reported of one case of APOP that diagnosed by bronchoscope guided lung biopsy,reviewed related literatures to summarize the clinical manifestations,pathological characteristics,treatment and prognosis of AFOP,in order to improve the understanding of clinicians.