Objective To explore the relationship between mean platelet volume(MPV)and left ventricular systolic function of patients with ST-segment elevation myocardial infarction.Methods From 2014-10-01 to 2016-05-01,a total of 117 first-visit patients with ST-segment elevation myocardial infarction were selected in the Department of Cardiology,Shanghai East Hospital,and they were divided into control group(without left ventricular systolic function damage,n=83)and observation group(with left ventricular systolic function damage,n=34)according to the incidence of left ventricular systolic function damage.Clinical data of the two groups was retrospectively analyzed,including general information,laboratory examination results and drugs usage before admission,and the influencing factors of left ventricular systolic function of patients with ST-segment elevation myocardial infarction was analyzed by multivariate Logistic regression analysis.Results No statistically significant differences of gender,waistline,incidence of diabetes,hypertension,hyperlipemia,anterior myocardial infarction or angina pectoris before myocardial infarction,smoking rate,duration between attack and admission,or duration between door-balloon expansion was found between the two groups(P>0.05),while age of observation group was statistically significantly older than that of control group(P<0.05).No statistically significant differences of TC,TG,HDL-C,LDL-C,HbA1c,Hb,haematocrit or PLT was found between the two groups(P>0.05);NT-proBNP of observation group was statistically significantly higher than that of control group,meanwhile MPV of observation group was statistically significantly larger than that of control group(P<0.05).No statistically significant differences of proportion of patients using ACEI/ ARB,using β-blockers,using calcium channel blockers,using warfarin,using diuretic,using aspirin or using clopidogrel was found between the two groups(P>0.05).Multivariate Logistic regression analysis results showed that,MPV was the independent risk factor of left ventricular systolic function damage of patients with ST-segment elevation myocardial infarction 〔OR=3.640,95%CI(3.047,9.440),P<0.05〕.Conclusion Increase of MPV is correlated with left ventricular systolic function damage of patients with ST-segment elevation myocardial infarction.%目的 分析平均血小板体积(MPV)与ST段抬高型心肌梗死(STEMI)患者左心室收缩功能的关系.方法 选取2014-10-01-2016-05-01在同济大学附属东方医院心内科住院的首诊STEMI患者117例,根据是否伴有左心室收缩功能损伤分为对照组83例(无左心室收缩功能损伤)和观察组34例(有左心室收缩功能损伤).回顾性分析两组患者的病历资料,记录其一般资料、实验室检查指标及入院前药物使用情况,并采用多因素Logistic回归分析STEMI患者左心室收缩功能损伤的影响因素.结果 两组患者性别、腰围、糖尿病发生率、高血压发生率、高脂血症发生率、前壁心肌梗死发生率、梗死前心绞痛发生率、吸烟率、发病至就诊时间及门-球囊扩张时间比较,差异无统计学意义(P>0.05);观察组患者年龄大于对照组(P<0.05).两组患者总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、血红蛋白水平及血细胞比容、血小板计数比较,差异无统计学意义(P>0.05);观察组患者氨基末端脑钠肽前体水平高于对照组,MPV大于对照组(P<0.05).两组患者中使用血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体拮抗剂、β-受体阻滞剂、钙通道阻滞剂、华法林、利尿剂、阿司匹林及氯吡格雷者所占比例比较,差异无统计学意义(P>0.05).多因素Logistic回归分析结果显示,MPV是STEMI患者左心室收缩功能损伤的独立影响因素〔OR=3.640,95%CI(3.047,9.440),P<0.05〕.结论 MPV增大与STEMI患者左心室收缩功能损伤有关.
展开▼
